Increasing access to healthy food has become a key focus area of efforts to reduce chronic diseases and to end hunger and food insecurity. The efforts have largely focused on improving the availability and affordability of whole grains, fruits, vegetables, and lean protein sources.  Efforts to promote access to healthy food can be the source of concerns about safety surrounding how food is grown and handled. Opportunities for intentional and/or unintentional breaches in the food system, which may put the public at risk and hinder market access, could be created.  Food safety measures are likely to increase food costs and may decrease the production of some crops due to risks. What is an appropriate level of protection (ALOP),  and is it necessary to reconcile differences in standards based on the wealth of nations and within nations? How will proposed regulation impact safety and international trade of nutritionally important crops? Can we take lessons from environmental protection standards and effects on competitiveness of industries in a global market, or will the focus be on an individual country basis? With limited resources, should small producers be the focus of any outreach efforts when the relative risk to the population is low? As demand for increased food safety is happening as the world’s population is expanding, are there choices to be made for seeking a balance between food safety and food availability?