Biophysical Parameters Affecting Gene Transfer in the Food Chain: First Results from the EFFORT FP7 EU Project

Microbial antibiotic resistance (AMR) is widely accepted as a growing concern. It is well recognized that the application of antibiotics in human clinical therapy, agriculture and aquaculture, all contribute to the emergence and persistence of antibiotic resistance due to selective pressure. Throughout the food chain, from live animals to retail, bacteria are subjected to harsh conditions. These conditions often stress the microorganisms, and may enhance horizontal gene transfer between bacteria and thus spread antimicrobial resistance determinants.

Therefore the main aim of this presentation is to present an deep analysis of the conditions to which the bacteria are subjected throughout the food chain. The conditions have been analysed and classified for the demonstrated or potential role in enhancing dissemination of antimicrobial resistance determinants.  Further, we’ll show how knowledge gaps are being filled using experimental approaches in order to establish their potential effect on gene transfer and selection pressure.