Vibrio spp. are a predominant cause of seafood-associated illnesses, globally, and vibriosis in one of the few foodborne diseases that has trended upwards in the United States.  As Vibrio spp. are naturally ubiquitous organisms in the marine environment, strategies for mitigation of this hazard are particularly challenging.  Vibriosis is primarily associated with the consumption of molluscan shellfish, which is regulated through the National Shellfish Sanitation Program (NSSP).  Changes in the NSSP approach to mitigating the risk of vibriosis will be discussed, including the emerging challenge of shellfish aquaculture.  However, there are other sources of Vibrio spp. infections that will be highlighted.  The panel will, also, include discussions on the applications of next generation sequencing (NGS), which have led to a better understanding of Vibrio strains that are more likely to cause human illnesses.  How is this new information being incorporated into management strategies?  With advancements in ecological forecasting abilities, what possibilities exist for mitigation of vibriosis?  These topics and more will be discussed by federal, state, academic, and non-government organization (NGO) representatives to facilitate a comprehensive dialogue about changing the upward trend of vibriosis associated with seafood products.