Worldwide public health organizations are moving into the world of Whole Genome Sequencing (WGS) as the standard for molecular characterization. This presents many advantages; however, there are still some issues to work through. This roundtable will explore the myriad of standardization issues, such as nomenclature (static versus dynamic, multi-locus, etc), pipelines, criteria, and future developments in platforms, metagenomics, and other topics we may not even be aware of yet. The round table panelists will discuss how their organizations are navigating these issues and the current status of WGS implementation.